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Article

PINK1‐mediated mitophagy maintains pluripotency through optineurin

1 May 2021

Abstract excerpt

Abstract Objectives Dysfunction of autophagy results in accumulation of depolarized mitochondria and breakdown of self‐renewal and pluripotency in ESCs. However, the regulators that control how mitochondria are degraded by autophagy for pluripotency regulation remains largely unknown. This study aims to dissect the molecular mechanisms that regulate mitochondrial homeostasis for pluripotency regulation in mouse...

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Share to Autophagy in Disease and Therapy
Share to Mitochondrial Function and Pathology
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PMID: 33931895
DOI: 10.1111/cpr.13034

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