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Article

Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

13 Jun 2016

Abstract excerpt

Our understanding on how selective mitochondrial autophagy, or mitophagy, can sustain the archetypal properties of stem cells is incomplete. PTEN-induced putative kinase 1 (PINK1) plays a key role in the maintenance of mitochondrial morphology and function and in the selective degradation of damaged mitochondria by mitophagy. Here, using embryonic fibroblasts fromPINK1 gene-knockout (KO) mice, we evaluated...

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PMID: 27295498
DOI: 10.18632/aging.100976

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