Article
Simultaneous Induction of Glycolysis and Oxidative Phosphorylation during Activation of Hepatic Stellate Cells Reveals Novel Mitochondrial Targets to Treat Liver Fibrosis.
Cells - 11 Nov 2020
Smith-Cortinez Natalia, van Eunen Karen, Heegsma Janette, Serna-Salas Sandra Alejandra, Sydor Svenja, Bechmann Lars P, Moshage Han, Bakker Barbara M, Faber Klaas Nico
Abstract excerpt
Upon liver injury, hepatic stellate cells (HSCs) transdifferentiate to migratory, proliferative and extracellular matrix-producing myofibroblasts (e.g., activated HSCs; aHSCs) causing liver fibrosis. HSC activation is associated with increased glycolysis and glutaminolysis. Here, we compared the contribution of glycolysis, glutaminolysis and mitochondrial oxidative phosphorylation (OXPHOS) in rat and human HSC...
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