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The single-cell and spatial transcriptional landscape of human gastrulation and early brain development

15 May 2023

Abstract excerpt

The emergence of the three germ layers and the lineage-specific precursor cells orchestrating organogenesis represent fundamental milestones during early embryonic development. We analyzed the transcriptional profiles of over 400,000 cells from 14 human samples collected from post-conceptional weeks (PCW) 3 to 12 to delineate the dynamic molecular and cellular landscape of early gastrulation and nervous system...

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PMID: 37192616
DOI: 10.1016/j.stem.2023.04.016

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