Article

Characterising molecular and cellular mechanisms of human brain evolution using brain organoids

2020-01-01

Abstract excerpt

The evolutionary lineage of humans is marked by a rapid expansion in brain size. Efforts to study human brain evolution have characteristically relied on anatomical and genomic comparisons between adult ape brains, meaning that the molecular mechanisms underlying human-specific brain expansion remain largely unknown. In this work we show that brain organoids can be used to identify and functionally test mechanisms...

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Literature Corpus work: bbf9207f-4bef-5342-a1ab-497657a9ca35
DOI: 10.17863/cam.74473

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