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Article

Combining mutation and recombination statistics to infer clonal families in antibody repertoires.

eLife - 9 Aug 2024

Spisak Natanael, Athènes Gabriel, Dupic Thomas, Mora Thierry, Walczak Aleksandra M

Abstract excerpt

B-cell repertoires are characterized by a diverse set of receptors of distinct specificities generated through two processes of somatic diversification: V(D)J recombination and somatic hypermutations. B-cell clonal families stem from the same V(D)J recombination event, but differ in their hypermutations. Clonal families identification is key to understanding B-cell repertoire function, evolution, and dynamics. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39120133
DOI: 10.7554/eLife.86181
PMCID: PMC11441979

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