Article

Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data

2020-07-22

Abstract excerpt

Somatic hypermutations of immunoglobulin (Ig) genes occurring during affinity maturation drive B-cell receptors’ ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain regions of the Ig gene being preferentially targeted. However, a rigorous quantification of this bias has been difficult because of phylogenetic correlations between sequen...

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Literature Corpus work: 2816073e-ff95-5a9a-8064-25afc622e0e7
DOI: 10.1101/2020.07.21.213686

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