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Article

Somatic hypermutation analysis for improved identification of B cell clonal families from next-generation sequencing data.

PLoS computational biology - 1 Jun 2020

Nouri Nima, Kleinstein Steven H

Abstract excerpt

Adaptive immune receptor repertoire sequencing (AIRR-Seq) offers the possibility of identifying and tracking B cell clonal expansions during adaptive immune responses. Members of a B cell clone are descended from a common ancestor and share the same initial V(D)J rearrangement, but their B cell receptor (BCR) sequence may differ due to the accumulation of somatic hypermutations (SHMs). Clonal relationships are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, B-Cell

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Source

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Identifiers

PMID: 32574157
DOI: 10.1371/journal.pcbi.1007977
PMCID: PMC7347241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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