Article

Somatic hypermutation analysis for improved identification of B cell clonal families from next-generation sequencing data

2019-10-01

Abstract excerpt

<h4>Motivation</h4> Adaptive immune receptor repertoire sequencing (AIRR-Seq) offers the possibility of identifying and tracking B cell clonal expansions during adaptive immune responses. Members of a B cell clone are descended from a common ancestor and share the same initial V(D)J rearrangement, but their B cell receptore (BCR) sequence may differ due to the accumulation of somatic hypermutations (SHMs). Clonal...

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Literature Corpus work: 7fe027b7-7d32-5758-88b5-f9f50304ad0b
DOI: 10.1101/788620

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