Article

Knowledge-based antibody repertoire simulation, a novel allele detection tool evaluation and application

2021-07-02

Abstract excerpt

Detailed knowledge of the diverse immunoglobulin germline genes is critical for the study of humoral immunity. Hundreds of alleles have been discovered by analyzing antibody repertoire sequencing (Rep-seq or Ig-seq) data via multiple novel allele detection tools (NADTs). However, the performance of these NADTs through antibody sequences with intrinsic somatic hypermutations (SHMs) is unclear. Here, we developed a...

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Literature Corpus work: 5863bd1b-ce35-5d26-b1ca-0553975c9932
DOI: 10.1101/2021.07.01.450681

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