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Article

Rearrangement of T Cell Genome Architecture Regulates GVHD

2021-01-24

Abstract excerpt

The cohesin complex modulates gene expression and cellular functions by shaping three-dimensional (3D) organization of chromatin. WAPL, cohesin’s DNA release factor, regulates 3D chromatin architecture. The 3D genome structure and its relevance to mature T cell functions in vivo is not well understood. We show that in vivo lymphopenic expansion, and allo-antigen driven proliferation, alters the 3D structure and...

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Identifiers and source

Literature Corpus work
f495582f-426a-5c65-87b7-3a665c95713e
DOI
10.1101/2021.01.23.427857
Open publication

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Rearrangement of T Cell Genome Architecture Regulates GVHDDOI 10.1101/2021.01.23.427857
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