Article

Carcinoma-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment

2023-04-13

Abstract excerpt

<h4>ABSTRACT</h4> Tumor heterogeneity is a major driver of cancer progression. In epithelial-derived malignancies, carcinoma-associated fibroblasts (CAFs) contribute to tumor heterogeneity by depositing extracellular matrix (ECM) proteins that dynamically remodel the tumor microenvironment (TME). Ewing sarcomas (EwS) are histologically monomorphous, mesenchyme-derived tumors that are devoid of CAFs. Here we ident...

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Literature Corpus work: 7f616065-be0e-50e9-9084-5aa954971028
DOI: 10.1101/2023.04.12.536619

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