Article

Single-cell RNA Profiling Identifies Diverse Cellular Responses to EWSR1-FLI1 Down-regulation in Ewing Sarcoma

2019-08-30

Abstract excerpt

<h4>ABSTRACT</h4> Single-cell analyses provide insight into time dependent behaviors in response to dynamic changes of oncogene expression. We developed an unbiased approach to study gene expression variation using a model of cellular dormancy induced via EWSR1-FLI1 down-regulation in Ewing sarcoma (EWS) cells. We propose that variation in the expression of EWSR1-FLI1 over time determines cellular responses. Cell...

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Literature Corpus work: c951c534-9bd1-5f71-8ed1-fc5166b59a35
DOI: 10.1101/750539

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