Article

Magnitude and timing of the antiviral response determine SARS-CoV-2 replication early in infection

2021-01-26

Abstract excerpt

The interferon response is a potent antiviral defense mechanism, but its effectiveness depends on its timing relative to viral replication. Here, we report viral replication and host response kinetics in patients at the start of SARS-CoV-2 infection and explore the impact of these kinetics experimentally. In both longitudinal patient nasopharyngeal samples and airway epithelial organoids, we found that SARS-CoV-2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fb6b454d-eba7-5171-ad14-a1aecc6a13dc
DOI: 10.1101/2021.01.22.21249812

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Magnitude and timing of the antiviral response determine SARS-CoV-2 replication early in infectionDOI 10.1101/2021.01.22.21249812Read

SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial CellsSemantic proximity Read

SARS-CoV-2 replication triggers an MDA-5-dependent interferon production which is unable to efficiently control replicationSemantic proximity Read

Type I interferons and SARS-CoV-2: from cells to organismsSemantic proximity Read

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2Semantic proximity Read

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2Semantic proximity Read

Mechanisms of impairment of interferon production by SARS-CoV-2Semantic proximity Read

Role of interferons in the antiviral battle: from virus-host crosstalk to prophylactic and therapeutic potential in SARS-CoV-2 infectionSemantic proximity Read

Early Mucosal Type II Interferon Limits SARS-CoV-2 Replication in HumansSemantic proximity Read

Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replicationSemantic proximity Read

Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responsesSemantic proximity Read

Interferon antagonists encoded by SARS-CoV-2 at a glanceSemantic proximity Read

Non-severe SARS-CoV-2 infection is characterised by very early T cell proliferation independent of type 1 interferon responses and distinct from other acute respiratory virusesSemantic proximity Read