Article

Early Mucosal Type II Interferon Limits SARS-CoV-2 Replication in Humans

2026-07-01

Abstract excerpt

<h4>ABSTRACT</h4> COVID-19 vaccines markedly reduce disease severity, but their ability to block infection and transmission remains limited and variable. 1 A better understanding of early mucosal immune programs that constrain viral replication at susceptible upper respiratory sites is needed to develop more effective antiviral strategies. However, temporal and anatomical antiviral dynamics are difficult to reso...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 305608c1-e983-5249-a28e-89715c85a92d
DOI: 10.64898/2026.06.29.26356894

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early Mucosal Type II Interferon Limits SARS-CoV-2 Replication in HumansDOI 10.64898/2026.06.29.26356894Read

Mucosal and Systemic Immune Correlates of Viral Control following SARS-CoV-2 Infection Challenge in Seronegative AdultsSemantic proximity Read

Mucosal gene expression in response to SARS-CoV-2 is associated with early viral loadSemantic proximity Read

Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2Semantic proximity Read

Mucosal and systemic immune dynamics associated with COVID-19 outcomes: a longitudinal prospective clinical studySemantic proximity Read

SARS-CoV-2-Specific Immune Responses in Vaccination and Infection during the Pandemic in 2020–2022Semantic proximity Read

Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversionSemantic proximity Read

Systems Vaccinology Reveals Distinct Immune Signatures of Inhaled and Intramuscular SARS-CoV-2 Vaccination in HumansSemantic proximity Read

Human nasal and lung tissues infected <i>ex vivo</i> with SARS-CoV-2 provide insights into differential tissue-specific and virus-specific innate immune responses in the upper and lower respiratory tractSemantic proximity Read

Human SARS-CoV-2 challenge resolves local and systemic response dynamicsSemantic proximity Read

Early immune responses have long-term associations with clinical, virologic, and immunologic outcomes in patients with COVID-19Semantic proximity Read

Early immune responses have long-term associations with clinical, virologic, and immunologic outcomes in patients with COVID-19Semantic proximity Read

Human SARS-CoV-2 challenge uncovers local and systemic response dynamicsSemantic proximity Read