Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses

26 Apr 2021

Abstract excerpt

Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data also suggest that timing and extent of IFN production is associated with manifestation of COVID-19 severity. In spite of progress in understanding how SARS-CoV-2 activates antiviral responses, mechanistic studies into wild-type...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to interferon and immune responses
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33937724
DOI: 10.1016/j.isci.2021.102477

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responsesPMID 33937724Read ↗

SARS-CoV-2 replication triggers an MDA-5-dependent interferon production which is unable to efficiently control replicationSemantic proximity Read ↗

Type I interferons and SARS-CoV-2: from cells to organismsSemantic proximity Read ↗

Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial CulturesSemantic proximity Read ↗

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial CulturesSemantic proximity Read ↗

Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patientsSemantic proximity Read ↗

Surface proteins of SARS-CoV-2 drive airway epithelial cells to induce interferon-dependent inflammationSemantic proximity Read ↗

Pathophysiology of acute respiratory syndrome coronavirus 2 infection: a systematic literature review to inform EULAR points to consider.Semantic proximity Read ↗

SARS-CoV-2 Nsp2 Contributes to Inflammation by Activating NF-κBSemantic proximity Read ↗

SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial CellsSemantic proximity Read ↗

Differential interferon-α subtype immune signatures suppress SARS-CoV-2 infectionSemantic proximity Read ↗

Protective Potentials of Type III Interferons in COVID-19 Patients: Lessons from Differential Properties of Type I- and III InterferonsSemantic proximity Read ↗

SARS-CoV-2 type I Interferon modulation by nonstructural proteins 1 and 2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.