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Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

7 Dec 2021

Abstract excerpt

The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and transmission, and may initiate the host response to SARS-CoV-2. Antiviral interferon (IFN) responses are critical to outcome of SARS-CoV-2. Yet little is known about the interaction between SARS-CoV-2 and innate immunity in this tissue. Here we apply single-cell RNA sequencing and proteomics to a primary cell model of human...

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PMID: 34876592
DOI: 10.1038/s41467-021-27318-0

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