Article

Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replication

2021-11-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Common alphacoronaviruses and human rhinoviruses (HRV) induce type I and III interferon (IFN) responses important to limiting viral replication in the airway epithelium. In contrast, highly pathogenic betacoronaviruses including SARS-CoV-2 may evade or antagonize RNA-induced IFN I/III responses. <h4>Methods</h4> In airway epithelial cells (AECs) from children and older ad...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 205b10de-51a6-569f-98c5-d998aaf4cddf
DOI: 10.1101/2021.11.20.469409

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replicationDOI 10.1101/2021.11.20.469409Read

Differential interferon-α subtype immune signatures suppress SARS-CoV-2 infectionSemantic proximity Read

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2Semantic proximity Read

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial CulturesSemantic proximity Read

An Endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cellsSemantic proximity Read

Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responsesSemantic proximity Read

Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial CulturesSemantic proximity Read

A distinct signature of interferon-stimulated genes linked to cross-protection against secondary viral infections in primary bronchial epithelial cellsSemantic proximity Read

Type I interferons and SARS-CoV-2: from cells to organismsSemantic proximity Read

SARS-CoV-2 replication triggers an MDA-5-dependent interferon production which is unable to efficiently control replicationSemantic proximity Read

The adult nasal mucosa is defined by distinct immune profiles that modulate in-vitro SARS-CoV-2 infection.Semantic proximity Read

Multiple layers of innate immune response antagonism of SARS-CoV-2Semantic proximity Read