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Type I interferons and SARS-CoV-2: from cells to organisms

25 Jan 2022

Abstract excerpt

Type I interferons (IFNs) have broad and potent antiviral activity. We review the interplay between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro produce low levels of type I IFNs, and SARS-CoV-2 proteins can inhibit various steps in type I IFN production and response. Exogenous type I IFNs inhibit viral growth in vitro. In various animal species infected in vivo, type I IFN...

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COVID-19 Clinical Research Studies
interferon and immune responses
SARS-CoV-2 and COVID-19 Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35149239
DOI: 10.1016/j.coi.2022.01.003

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