Article

SARS-CoV-2 replication triggers an MDA-5-dependent interferon production which is unable to efficiently control replication

2020-10-28

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third highly pathogenic coronavirus to spill over to humans in less than 20 years, after SARS-CoV-1 in 2002-2003 and Middle East respiratory syndrome (MERS)-CoV in 2012. SARS-CoV-2 is the etiologic agent of coronavirus disease 19 (COVID-19), which ranges from mild respiratory symptoms to severe lung injury and death in the most severe cases. The C...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1fd8c31-62a8-58d8-a528-871879f24e76
DOI: 10.1101/2020.10.28.358945

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 replication triggers an MDA-5-dependent interferon production which is unable to efficiently control replicationDOI 10.1101/2020.10.28.358945Read

SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial CellsSemantic proximity Read

Mechanisms of impairment of interferon production by SARS-CoV-2Semantic proximity Read

Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responsesSemantic proximity Read

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial CulturesSemantic proximity Read

Type I interferons and SARS-CoV-2: from cells to organismsSemantic proximity Read

Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial CulturesSemantic proximity Read

Protective Potentials of Type III Interferons in COVID-19 Patients: Lessons from Differential Properties of Type I- and III InterferonsSemantic proximity Read

Role of interferons in the antiviral battle: from virus-host crosstalk to prophylactic and therapeutic potential in SARS-CoV-2 infectionSemantic proximity Read

Interferon antagonists encoded by SARS-CoV-2 at a glanceSemantic proximity Read

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial CellsSemantic proximity Read

Differential roles of RIG-I-like receptors in SARS-CoV-2 infectionSemantic proximity Read