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Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

2021-02-17

Abstract excerpt

The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and transmission, and may initiate the host response to SARS-CoV-2. Antiviral interferon (IFN) responses are critical to outcome of SARS-CoV-2. Yet little is known about the interaction between SARS-CoV-2 and innate immunity in this tissue. Here we applied single-cell RNA sequencing and proteomics to a primary cell model of huma...

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Literature Corpus work
ebb1014e-de21-5a73-8024-08f7ea9e4f4f
DOI
10.1101/2021.02.17.431591
Open publication

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Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2DOI 10.1101/2021.02.17.431591
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