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Pan-cancer discovery of driver mutations in long noncoding RNAs reveals widespread functional rewiring of RNA regulatory elements

2026-06-12

Abstract excerpt

Most somatic mutations in cancer occur outside protein-coding genes, yet the functional impact of these mutations remains largely unknown. Long noncoding RNAs (lncRNAs) represent a major class of cancer-promoting genes whose molecular mechanisms are poorly understood. While individual driver mutations in lncRNAs have been identified, detecting such ‘driver lncRNAs’ at scale requires large tumour genome cohorts. We...

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Literature Corpus work
58c3eb44-bfe4-5d38-a83d-b91be65060fd
DOI
10.64898/2026.06.10.730876
Open publication

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