Article

HDAC inhibitor treatment restores transcriptome, chromatin accessibility and memory deficits in a mouse model for Down syndrome

2026-03-20

Abstract excerpt

<h4>Summary</h4> Down syndrome (DS) is associated with widespread molecular alterations, including aberrant gene expression, which not only affects chromosome 21 genes but perturbs the whole transcriptome. The genome-wide nature of this alteration suggests that it might be epigenetically mediated, which may also offer therapeutic opportunities given the reversibility of epigenetic modifications. Here, we show tha...

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Literature Corpus work: fb55ddb4-94ae-5320-bd37-0cdf7731065e
DOI: 10.64898/2026.03.20.712945

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