Article

Single nucleus RNA-seq in the hippocampus of a Down syndrome mouse model reveals new key players in memory

2021-11-18

Abstract excerpt

Down syndrome (DS) is the most common genetic cause of intellectual disability. Even though great advances in the last decades have allowed better delineation of its pathogenetic mechanisms, its cellular and molecular bases are still poorly understood. To evaluate the consequences of chromosome aneuploidy on the hippocampus, we analyzed single-nucleus transcriptional profiles of the DS mouse model Ts65Dn. Our data...

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Literature Corpus work: 76a3a6dc-65e0-5617-b058-e9ae6e0330e2
DOI: 10.1101/2021.11.18.469102

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