Article

Cognitive and molecular characterization of the Ts66Yah murine model of Down syndrome: deepening on hippocampal changes associated with genotype and aging

2024-01-02

Abstract excerpt

<h4>ABSTRACT</h4> Down syndrome (DS) is the most common condition with intellectual disability and is caused by trisomy of Homo sapiens chromosome 21 (HSA21). The increased dosage of genes on HSA21 is the cause for the initial neurodevelopmental disorder and for further development of cognitive decline, however the molecular mechanisms promoting brain pathology along ageing are still missing. One of the major ch...

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Literature Corpus work: 210e6a7b-ac9e-5c38-9234-23ae585e16b2
DOI: 10.1101/2024.01.02.573811

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