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The lncRNA Snhg11 is required for synaptic function, neurogenesis and memory and is downregulated in the dentate gyrus of Down syndrome mouse models

2022-09-16

Abstract excerpt

<title>Abstract</title> <p>Down syndrome (DS) is the most common genetic cause of intellectual disability. Even though advances in the last decades have allowed better delineation of its pathogenetic mechanisms, its cellular and molecular bases are still poorly understood. Here, single-nuclei transcriptional profiles of the hippocampus of a DS mouse model revealed that the trisomy results in a highly cell-type sp...

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Literature Corpus work
b8f2b7f7-4249-5fda-99b6-d4861e4327d7
DOI
10.21203/rs.3.rs-2014117/v1
Open publication

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