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Article

Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms.

Neuroscience research - 1 Dec 2007

Rachidi Mohammed, Lopes Carmela

Abstract excerpt

Down syndrome (DS), the most frequent genetic disorder leading to mental retardation (MR), is caused by three copies of human chromosome 21 (HC21). Trisomic and transgenic mouse models for DS allow genetic dissection of DS neurological and cognitive disorders in view to identify genes responsible for these phenotypes. The effects of the gene dosage imbalance on DS phenotypes are explained by two hypotheses: the...

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Identifiers

PMID: 17897742
DOI: 10.1016/j.neures.2007.08.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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