Article

Novel monoclonal antibodies against the C-terminal HEAT domain of Huntingtin

2025-09-17

Abstract excerpt

<h4>BACKGROUND</h4> Reliable detection of huntingtin (HTT) is essential for understanding Huntington’s disease (HD) biology and evaluating therapeutic strategies. However, high-quality monoclonal antibodies (mAbs) against the HTT C-terminal domain remain limited. <h4>OBJECTIVE</h4> We sought to generate and validate novel monoclonal antibodies targeting the HTT C-terminal HEAT-containing domain to better detect...

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Literature Corpus work: 676fbab6-9308-52f8-ba0a-0d9e7003252f
DOI: 10.1101/2025.09.17.676860

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