Article

Macrocyclic Peptide Tools for Huntingtin-bound HAP40

2026-06-02

Abstract excerpt

Huntington’s disease is a fatal neurodegenerative disorder caused by expansion of a cytosine-adenosine-guanine repeat in exon 1 of the Huntingtin (HTT) gene, resulting in a polyglutamine-expanded HTT protein. Although the genetic cause of Huntington’s is well defined, the molecular functions of HTT and the mechanisms linking polyglutamine expansion to neurodegeneration remain incompletely understood. Huntingtin As...

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Literature Corpus work: b24a3290-d784-5870-87b7-daf910718211
DOI: 10.64898/2026.06.02.729325

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