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Article

Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.

Diabetes - 1 Jul 2012

Rosengren Anders H, Braun Matthias, Mahdi Taman, Andersson Sofia A, Travers Mary E, Shigeto Makoto, Zhang Enming, Almgren Peter, Ladenvall Claes, Axelsson Annika S, Edlund Anna, Pedersen Morten Gram, Jonsson Anna, Ramracheya Reshma, Tang Yunzhao, Walker Jonathan N, Barrett Amy, Johnson Paul R V, Lyssenko Valeriya, McCarthy Mark I, Groop Leif, Salehi Albert, Gloyn Anna L, Renström Erik, Rorsman Patrik, Eliasson Lena

Abstract excerpt

The majority of genetic risk variants for type 2 diabetes (T2D) affect insulin secretion, but the mechanisms through which they influence pancreatic islet function remain largely unknown. We functionally characterized human islets to determine secretory, biophysical, and ultrastructural features in relation to genetic risk profiles in diabetic and nondiabetic donors. Islets from donors with T2D exhibited impaired...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22492527
DOI: 10.2337/db11-1516
PMCID: PMC3379663

Genes

KCNJ11
KCNQ1
HHEX
IDE

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