Article

Mitochondrial and protein homeostasis pathways are transcriptionally impaired in islets during type 1 diabetes pathogenesis

2026-08-03

Abstract excerpt

The decline in first-phase insulin response (FPIR) during the presymptomatic period of type 1 diabetes (T1D) is well established. In-situ functional studies with pancreas tissue slices showed that β-cell loss of glucose-responsiveness was independent of T-cell infiltration into islets in recent-onset T1D cases. However, the mechanisms driving β-cell dysfunction before the onset of T1D remain unclear. In pancreas...

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Literature Corpus work: 818b7450-4244-5261-838f-274a7b343ba7
DOI: 10.64898/2026.07.29.741469

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