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Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

22 Sept 2016

Abstract excerpt

Hormone-secreting cells within pancreatic islets of Langerhans play important roles in metabolic homeostasis and disease. However, their transcriptional characterization is still incomplete. Here, we sequenced the transcriptomes of thousands of human islet cells from healthy and type 2 diabetic donors. We could define specific genetic programs for each individual endocrine and exocrine cell type, even for rare δ,...

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Identifiers

PMID: 27667667
DOI: 10.1016/j.cmet.2016.08.020

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