Article

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition

2022-09-13

Abstract excerpt

<h4>SUMMARY</h4> Within the chromatin, distal elements interact with promoters to regulate specific transcriptional programs. Histone acetylation, interfering with the net charges of the nucleosomes, is a key player in this regulation. Here, we report that the onco-protein SET is a critical determinant for the levels of histone acetylation within enhancers. We disclose that conditions in which SET is accumulated,...

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Literature Corpus work: fb2e636e-2b15-5136-95ce-95974dff2780
DOI: 10.1101/2022.09.12.507599

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