Back to search

Article

Exosome-Induced In Situ Oncogenic Transformation: A Hypothesis for Metastasis (EMMT)

2025-12-29

Abstract excerpt

This Perspective proposes a novel conceptual model of metastasis termed Exosome-Mediated Malignant Transformation (EMMT). In this model, dissemination occurs not through physical migration of tumor cells [1-3] but via circulating tumor exosomes (CTEs). These vesicles deliver oncogenic prion-like proteins, epigenetic regulators, and retrotransposons that selectively target distant recipient cells with unresolved DN...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ef154bd6-a21a-5be0-afcc-9d0ebc166fa4
DOI
10.20944/preprints202512.2549.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Exosome-Induced In Situ Oncogenic Transformation: A Hypothesis for Metastasis (EMMT)DOI 10.20944/preprints202512.2549.v1
The Macrophage Niche as a Primary Oncogenic Architect: A Two-Hit Systems Biology HypothesisSemantic proximity
You complete me: tumor cell-myeloid cell nuclear fusion as a facilitator of organ-specific metastasisSemantic proximity
Cancer Cell Fusion: Mechanisms Slowly UnravelSemantic proximity
Organotropic metastasis: role of tumor exosomesSemantic proximity
Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in Metastasis.Semantic proximity
Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancerSemantic proximity
Tumor-derived cell-free DNA and circulating tumor cells: partners or rivals in metastasis formation?Semantic proximity
Cell fusion as a driver of metastasis: re-evaluating an old hypothesis in the age of cancer heterogeneitySemantic proximity
The overall process of metastasis: From initiation to a new tumorSemantic proximity
The role of EMT and MET in cancer dissemination.Semantic proximity
The emerging roles of exosomes in tumor–stroma interactionSemantic proximity
Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformationSemantic proximity
Select a neighboring publication to make it the new centre.