Article

Functionally and metabolically divergent melanoma-associated macrophages originate from common bone-marrow precursors

2023-06-05

Abstract excerpt

Melanomas display high numbers of tumor-associated macrophages (TAMs), which correlate with worse prognosis. Harnessing macrophages for therapeutic purposes has been particularly challenging due to their heterogeneity, based on their ontogeny and function and driven by the tissue-specific niche. In the present study, we used the YUMM1.7 model to better understand melanoma TAM origin and dynamics during tumor progr...

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Identifiers and source

Literature Corpus work: 209c9645-8b43-5f28-9c05-43ececadcb51
DOI: 10.1101/2023.06.02.543515

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