Article

Polydatin Allosterically Inhibits CAPS-Mediated Vesicular Trafficking to Reverse Inflammatory Dyshomeostasis and ECM Destabilization in Osteoarthritis

2026-06-02

Abstract excerpt

<title>Abstract</title> Background The irreversible homeostatic destabilization of the extracellular matrix (ECM) constitutes the fundamental pathological hallmark of osteoarthritis (OA), yet the molecular governance of the chondrocyte secretome remains largely enigmatic. Methods In this study, we integrated multi-omic bioinformatics and single-cell RNA sequencing to identify Calcium-Dependent Secretion Activa...

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Literature Corpus work: fafcbf18-acce-57b3-b76e-b43a189fce56
DOI: 10.21203/rs.3.rs-9624470/v1

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Polydatin Allosterically Inhibits CAPS-Mediated Vesicular Trafficking to Reverse Inflammatory Dyshomeostasis and ECM Destabilization in OsteoarthritisDOI 10.21203/rs.3.rs-9624470/v1Read

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