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NFIC-mediated CaSR endocytosis defines a hyperactive TOMM20 <sup>high</sup> CHGA <sup>high</sup> oxyphil cell state as a pathological driver of autonomous secondary hyperparathyroidism

2026-05-09

Abstract excerpt

Secondary hyperparathyroidism (SHPT) is a debilitating complication of chronic kidney disease. Its clinical management is frequently compromised by calcimimetic resistance, a refractory state primarily driven by the progressive downregulation of the membrane calcium-sensing receptor (CaSR). Despite the centrality of CaSR as a therapeutic target, the mechanisms governing its aberrant expression and membrane localiz...

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Literature Corpus work
16ef178f-d6cf-5c61-8e92-ee13a0840ee6
DOI
10.64898/2026.05.06.723114
Open publication

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NFIC-mediated CaSR endocytosis defines a hyperactive TOMM20 <sup>high</sup> CHGA <sup>high</sup> oxyphil cell state as a pathological driver of autonomous secondary hyperparathyroidismDOI 10.64898/2026.05.06.723114
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