Article

Multi-Target Gene Therapy for Osteoarthritis: A Computational and Structural Analysis Framework

2026-02-04

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Osteoarthritis (OA) remains therapeutically intractable despite advances in regenerative medicine. Single-target interventions—including mesenchymal stromal cells, platelet-rich plasma, and gene therapies—consistently yield transient symptomatic relief without durable structural modification. <bold>Objective:</bold> This study proposes a multi-target gene t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cf155571-318c-59d4-bdaa-9bde64da1351
DOI: 10.21203/rs.3.rs-8774255/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-Target Gene Therapy for Osteoarthritis: A Computational and Structural Analysis FrameworkDOI 10.21203/rs.3.rs-8774255/v1Read

Multi-Target Gene Therapy for Osteoarthritis: Dual-Axis Modeling and In Silico ValidationSemantic proximity Read

Gene therapy pipelines for osteoarthritis: current innovations, operational challenges, and future directionsSemantic proximity Read

New treatment for osteoarthritis: Gene therapySemantic proximity Read

Navigating the Hurdles of Intra-articular AAV Gene TherapySemantic proximity Read

Osteoarthritis gene therapy in 2022Semantic proximity Read

Development of AAV-Mediated Gene Therapy Approaches to Treat Skeletal DiseasesSemantic proximity Read

Comparative intra-articular gene transfer of seven adeno-associated virus serotypes reveals that AAV2 mediates the most efficient transduction to mouse arthritic chondrocytesSemantic proximity Read

The evolving landscape of gene therapy strategies for the treatment of osteoarthritisSemantic proximity Read

Bioactivity-driven discovery of repurposable antivirals as OSCAR inhibitors that promote cartilage protection via transcriptomic reprogrammingSemantic proximity Read

A single versus multi-vector approach to treating post-traumatic osteoarthritis using scAAV2 IL-1ra or scAAV2 IL-1ra/IGF-I in an equine preclinical modelSemantic proximity Read

AAV mediated repression of Neat1 lncRNA combined with F8 gene augmentation mitigates pathological mediators of joint disease in haemophiliaSemantic proximity Read

A Multispecies, Modality-Agnostic Scalable In Vivo Mosaic Screening Platform for Therapeutic Target DiscoverySemantic proximity Read