Back to search

Article

Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3

2023-12-23

Abstract excerpt

<title>Abstract</title> <p>Cartilage aging is a quintessential feature of knee osteoarthritis, and extracellular matrix (ECM) stiffening is a typical feature of cartilage aging. However, the mechanism of ECM stiffening to influence chondrocytes and downstream molecules is still poorly understood. Here, we mimicked the physiological and pathological stiffness of human cartilage by using polydimethylsiloxane-based...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ca971907-a370-5b20-aa90-69db38e65aef
DOI
10.21203/rs.3.rs-3714960/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3DOI 10.21203/rs.3.rs-3714960/v1
Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integritySemantic proximity
Mechanical stress abnormalities promote chondrocyte senescence - The pathogenesis of knee osteoarthritisSemantic proximity
How are Aging and Osteoarthritis Related?Semantic proximity
ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosisSemantic proximity
Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damageSemantic proximity
Sliding Hydrogels Reveal the Modulation of Mechanosensing Attenuates the Inflammatory Phenotype of Osteoarthritic Chondrocytes in 3D.Semantic proximity
Substrate stiffness and viscoelasticity influence fibroblast senescenceSemantic proximity
ADSC-Enriched Adipose Extract Alleviates Cartilage Fibrosis in Temporomandibular Joint Osteoarthritis by Inhibiting Chondrocyte SenescenceSemantic proximity
The Mechanobiology of AgingSemantic proximity
Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrixSemantic proximity
Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1Semantic proximity
Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implicationsSemantic proximity
Select a neighboring publication to make it the new centre.