Article

SARS-CoV-2 3CLpro Main Protease Drives Cytoskeletal Reorganization and Tunnelling Nanotube Formation for Stealth Intercellular Infection

2024-02-21

Abstract excerpt

<title>Abstract</title> To identify and characterize roles for SARS-CoV-2 3CLpro main protease in promoting viral infection and dissemination, we employed Inactive Catalytic Domain Capture and proteomics to identify host cell interactors and substrates in the interactome of 3CLpro. Of 259 3CLpro interactors, 145 were associated with the cytoskeleton and its organisation. We det...

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Literature Corpus work: 6102b54d-4cc7-5522-adca-91378c266b9d
DOI: 10.21203/rs.3.rs-3918469/v1

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