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Synovial Fluid Extracellular Vesicles from Patients with Severe Osteoarthritis Differentially Promote a Pro-Catabolic, Inflammatory Chondrocyte Phenotype

2025-03-25

Abstract excerpt

Synovial inflammation is recognised as a pathological driver of osteoarthritis (OA), a degenerative joint disease involving cartilage degradation and joint pain. Since extracellular vesicles (EVs) have emerged as key mediators of cellular cross-talk, this study characterised synovial fluid EVs (SFEVs) in OA patients with varying disease severity, and determined their functional effects on OA articular chondrocytes...

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Literature Corpus work
471de94c-2e5a-5e7a-b693-b33f0cafea30
DOI
10.20944/preprints202503.1851.v1
Open publication

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Synovial Fluid Extracellular Vesicles from Patients with Severe Osteoarthritis Differentially Promote a Pro-Catabolic, Inflammatory Chondrocyte PhenotypeDOI 10.20944/preprints202503.1851.v1
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