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Article

Multi-Target Gene Therapy for Osteoarthritis: Dual-Axis Modeling and In Silico Validation

2026-08-13

Abstract excerpt

<title>Abstract</title> <p>Objective Osteoarthritis (OA) remains therapeutically intractable, with no approved disease-modifying OA drug. This study proposes and tests an in silico Dual-Axis Model in which inflammatory signaling and mechano-structural degradation form a coupled system requiring simultaneous intervention. <h4>Design:</h4> We integrated structural analysis of therapeutic proteins (IL-1Ra, SOX9, IG...

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Literature Corpus work
ee1e64e0-0269-5f0a-9554-ab0114ffb37d
DOI
10.21203/rs.3.rs-8774255/v4
Open publication

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