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A SP1-Driven Translational-Proteostatic Checkpoint Modulates the Autophagy-Proteasome Network

2026-04-08

Abstract excerpt

<title>Abstract</title> <p>Cellular homeostasis depends on the tightly coordinated transcription, translation, and proteostasis networks. How prolonged stress decouples these multi-dimensional networks to drive degenerative cell state drift remains unclear. Using chondrocytes, which endure long-term mechanical stress, as a model, we integrated human single-cell omics, spatial imaging, population genetics, and in...

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Identifiers and source

Literature Corpus work
f7236e88-3ba6-5862-adc5-10ba85cb6f08
DOI
10.21203/rs.3.rs-9285543/v1
Open publication

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A SP1-Driven Translational-Proteostatic Checkpoint Modulates the Autophagy-Proteasome NetworkDOI 10.21203/rs.3.rs-9285543/v1
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