Article

A multiscale modeling approach to study the role of mechanics and inflammation in pathophysiology of articular cartilage

2025-12-30

Abstract excerpt

Mechanical loading regulates chondrocyte health in articular cartilage. While physiological stimuli maintain homeostasis, supra-physiological stimuli from joint injuries disrupt it, leading to osteoarthritis (OA). OA is a prevalent degenerative joint disease affecting millions worldwide. OA progression involves complex mechanical and biochemical interactions across multiple length scales, which are challenging to...

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Literature Corpus work: f7e874be-56c7-5fd7-8610-230348023280
DOI: 10.64898/2025.12.29.696945

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