Article

Genetic expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy

2021-06-05

Abstract excerpt

<h4>SUMMARY</h4> Hyperactivation of mTOR signaling during fetal neurodevelopment alters neuron structure and function, leading to focal malformation of cortical development (FMCD) and intractable epilepsy. Recent evidence suggests increased cap-dependent translation downstream of mTOR contributes to FMCD formation and seizures. However, whether reducing overactive translation once the developmental pathologies ar...

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Literature Corpus work: faf0749f-9e1d-56a1-b9cd-962546c0e7bb
DOI: 10.1101/2021.06.04.445850

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