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Article

Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice

18 Nov 2020

Abstract excerpt

The causative link between focal cortical malformations (FCMs) and epilepsy is well accepted, especially among patients with focal cortical dysplasia type II (FCDII) and tuberous sclerosis complex (TSC). However, the mechanisms underlying seizures remain unclear. Using a mouse model of TSC- and FCDII-associated FCM, we showed that FCM neurons were responsible for seizure activity via their unexpected abnormal...

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PMID: 33208499
DOI: 10.1126/scitranslmed.abc1492

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