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Article

mTOR signaling in epilepsy: insights from malformations of cortical development.

Cold Spring Harbor perspectives in medicine - 1 Apr 2015

Crino Peter B

Abstract excerpt

Over the past decade enhanced activation of the mammalian target of rapamycin (mTOR)-signaling cascade has been identified in focal malformations of cortical development (MCD) subtypes, which have been collectively referred to as "mTORopathies." Mutations in mTOR regulatory genes (e.g., TSC1, TSC2, AKT3, DEPDC5) have been associated with several focal MCD highly associated with epilepsy such as tuberous sclerosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25833943
DOI: 10.1101/cshperspect.a022442
PMCID: PMC4382721

Genes

AKT3
DEPDC5
TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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