Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Depdc5 knockout rat: A novel model of mTORopathy.

Neurobiology of disease - 1 May 2016

Marsan Elise, Ishida Saeko, Schramm Adrien, Weckhuysen Sarah, Muraca Giuseppe, Lecas Sarah, Liang Ning, Treins Caroline, Pende Mario, Roussel Delphine, Le Van Quyen Michel, Mashimo Tomoji, Kaneko Takehito, Yamamoto Takashi, Sakuma Tetsushi, Mahon Séverine, Miles Richard, Leguern Eric, Charpier Stéphane, Baulac Stéphanie

Abstract excerpt

DEP-domain containing 5 (DEPDC5), encoding a repressor of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, has recently emerged as a major gene mutated in familial focal epilepsies and focal cortical dysplasia. Here we established a global knockout rat using TALEN technology to investigate in vivo the impact of Depdc5-deficiency. Homozygous Depdc5(-/-) embryos died from embryonic day 14.5...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic Development
Share to Gene Knockout Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanistic Target of Rapamycin Complex 1

Share to Multiprotein Complexes

Share to Rats, Inbred F344

Share to Rats, Wistar

Share to Sirolimus

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 26873552
DOI: 10.1016/j.nbd.2016.02.010

Genes

DEPDC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Depdc5 knockout rat: A novel model of mTORopathy.PMID 26873552Read ↗

Prevention of premature death and seizures in a Depdc5 mouse epilepsy model through inhibition of mTORC1.Semantic proximity Read ↗

Chronic mTORC1 inhibition rescues behavioral and biochemical deficits resulting from neuronal Depdc5 loss in mice.Semantic proximity Read ↗

Acute knockdown of Depdc5 leads to synaptic defects in mTOR-related epileptogenesis.Semantic proximity Read ↗

Second-hit mosaic mutation in mTORC1 repressor DEPDC5 causes focal cortical dysplasia–associated epilepsySemantic proximity Read ↗

Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling.Semantic proximity Read ↗

Mutations in mammalian target of rapamycin regulator DEPDC5 cause focal epilepsy with brain malformations.Semantic proximity Read ↗

mTOR pathway: Insights into an established pathway for brain mosaicism in epilepsy.Semantic proximity Read ↗

Dorsal telencephalon-specific Nprl2- and Nprl3-knockout mice: novel mouse models for GATORopathy.Semantic proximity Read ↗

Mosaic human cortical organoids model mTOR-related focal cortical dysplasia through DEPDC5 loss-of-functionSemantic proximity Read ↗

mTOR signaling pathway genes in focal epilepsies.Semantic proximity Read ↗

DEPDC5 as a potential therapeutic target for epilepsy.Semantic proximity Read ↗

mTOR signaling in epilepsy: insights from malformations of cortical development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.