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Article

New insights into a spectrum of developmental malformations related to mTOR dysregulations: challenges and perspectives

22 Mar 2019

Abstract excerpt

In recent years the role of the mammalian target of rapamycin (mTOR) pathway has emerged as crucial for normal cortical development. Therefore, it is not surprising that aberrant activation of mTOR is associated with developmental malformations and epileptogenesis. A broad spectrum of malformations of cortical development, such as focal cortical dysplasia (FCD) and tuberous sclerosis complex (TSC), have been...

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PMID: 30901081
DOI: 10.1111/joa.12956

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