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mTOR pathway: Insights into an established pathway for brain mosaicism in epilepsy.

Neurobiology of disease - 15 Jun 2023

Gerasimenko Anna, Baldassari Sara, Baulac Stéphanie

Abstract excerpt

The mechanistic target of rapamycin (mTOR) signaling pathway is an essential regulator of numerous cellular activities such as metabolism, growth, proliferation, and survival. The mTOR cascade recently emerged as a critical player in the pathogenesis of focal epilepsies and cortical malformations. The 'mTORopathies' comprise a spectrum of cortical malformations that range from whole brain (megalencephaly) and...

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Brain
Epilepsy
GTPase-Activating Proteins
Malformations of Cortical Development
Mosaicism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

TOR Serine-Threonine Kinases

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PMID: 37149062
DOI: 10.1016/j.nbd.2023.106144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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